RELIEVES PAIN AND INFLAMMATION
The combination of Paracetamol and Ibuprofen with a reasonable amount makes ALAXAN® a fast and effective pain reliever.
Each tablet contains:
Ibuprofen ............................................................ 200 mg
Paracetamol ........................................................ 325 mg
Lactose Monohydrate, Corn starch, Povidone, FDC Yellow # 6, Sodium Starch Glycolate, Syloid 244, Magnesium Stearate q.s.
DOSAGE AND INSTRUCTION FOR USE
Like other NSAIDs, the lowest effective dose of ibuprofen + paracetamol should be used for the shortest possible time.
Adult and children 12 years and older: Orally, 1 tablet every 6 hours as needed, or as directed by a doctor.
Do not take more than directed.
Do not take longer than 10 days, unless directed by a doctor.
You should not take this medicine if you are allergic to paracetamol, ibuprofen, aspirin, or other NSAIDs; if you have a history of stroke, heart attack, uncontrolled high blood pressure, or congestive heart failure; if you are pregnant or breastfeeding; active peptic ulcer; advanced kidney or liver disease; asthma or bronchospasm: bleeding disorder.
If an allergic reaction occurs, stop use and seek medical help right away.
If stomach upset occurs, take this medicine with food or milk.
Do not use with any other medicine containing paracetamol (prescription or non-prescription). If you are not sure whether a medicine contains paracetamol, ask a doctor.
If you are pregnant or breastfeeding, ask a doctor before use. It is especially important not to use ibuprofen during the last three months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.
ibuprofen+paracetamol, when taken within the recommended dose and duration of treatment, has a low incidence of side effects,
Ibuprofen: Ibuprofen shares the same side effects as other NSAIDs. Ibuprofen may cause stomach and intestinal side effects such as ulceration and/or bleeding; other side effects are indigestion, heartburn, nausea, vomiting, anorexia, diarrhea, constipation, mouth ulcers, flatulence, bloating and abdominal pain.
Ibuprofen may also cause harmful effects to the kidneys and the liver.
There have been occasional reports of side effects involving the blood and blood-forming tissues.
There have also been occasional reports of dizziness, drowsiness, malaise, lightheadedness, nervousness, headache, fatigue, emotional lability, paresthesia, hallucinations, and dream abnormalities.
Ibuprofen may cause side effects involving the ears and eyes such as tinnitus, decreased hearing, amblyopia, conjunctivitis, optic neuritis, diplopia and cataracts.
Skin rashes have been observed.
There have been rare reports of Stevens-Johnson syndrome, Lyell's syndrome and erythema multiforme which are serious types of allergy and may occur without warning. Symptoms of these serious types of allergy include multiple skin lesions, itching, fever, and joint pains.
Allergic reactions manifested as a syndrome of abdominal pain, fever, chills, nausea and vomiting have occasionally occurred. Whole-body allergic reaction (anaphylaxis), constriction of air passages of the lungs, dry mouth, gingival ulceration, and stuffy nose (rhinitis) have also been reported.
Other side effects are fluid retention, increased blood pressure, low blood pressure, stroke, and palpitations.
Paracetamol: Paracetamol, when taken within the recommended dose and duration of treatment, has a low incident of side effects. Skin rashes and minor stomach and intestinal disturbances have been reported.
OVERDOSE AND TREATMENT
Overdosage of paracetamol usually involves 4 phases with the following signs and symptoms:
Eating disorder, nausea, vomiting, malaise, and excessive sweating
Right upper abdominal pain or tenderness, liver enlargement which may be characterized by abdominal discomfort of "feeling full", elevated bilirubin and liver enzyme concentrations, prolongation of prothrombin time, and occasionally decreased urine output
Eating disorder, nausea, vomiting, and malaise recur and signs of liver (e.g., jaundice) and possibly kidney failure
Recovery or progression to fatal complete liver failure
The most frequently reported symptoms of ibuprofen overdose include abdominal pain, nausea, vomiting, fatigue (lethargy) and drowsiness. Other symptoms include headache, tinnitus, central nervous system depression, and convulsions. Excessive acidity of the blood (metabolic acidosis), coma, acute kidney failure and absence of spontaneous breathing (apnea) may rarely occur.
If you have taken more than the recommended dosage, consult a doctor or contact a Medical Center right away. Quick medical attention is important for adults as well as for children even if you do not notice any signs or symptoms.
Treatment includes using of gastric lavage. N-acetylcysteine is the effective antidote if treatment is started within 10 to 12 hours after overdose: however it may be of some benefit if treatment is started within 24 hours.
Aspirin decreases the amount of ibuprofen in the blood, while phenylbutazone, indomethacine, salicylates, and other NSAIDs (e.g., mefenamic acid, naproxen, diclofenac; ketoprofen) increase the risk of stomach and intestinal bleeding in patients receiving ibuprofen.
Ibuprofen increases the amount of lithium in the blood (increased risk of toxicity) probably by reducing excretion of lithium.
Ibuprofen may cause acute reduction of kidney function and blood pressure response to ACE inhibitors (e.g., captopril, enalapril, ramipril, imidapril, fosinopril, lisinopril). Ibuprofen may reduce the effect of diuretics such as furosemide and thiazide. When taken with anticoagulants (e.g., warfarin, dicumarol), or together with thrombolytic agents (e.g., streptokinase), ibuprofen may cause stomach and intestinal bleeding.
An increase in the International Normalized Ratio (INR), which may serve as a sign of increased risk for bleeding, may be observed when using paracetamol and warfarin at the same time. Paracetamol increases the anticoagulation effect of warfarin.
Medicines which stimulate the enzymes responsible for the metabolic activation of paracetamol such as medicines for convulsion (e.g., Phenobarbital) may increase susceptibility to the harmful effects to the liver.
Boxes of 5 blisters x 20 press-thru tablets Boxes of 25 strips x 4 tablets
KEEP OUT OF REACH OF CHILDREN
READ THE PACKAGE INSERT CAREFULLY BEFORE USE
FOR MORE INFORMATION, PLEASE ASK FOR DOCTOR'S ADVICE
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