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Clorpheniramin

Clorpheniramin
Product Code: SDK: VD-3743-07
Availability: 100
Price: 15,000đ
Quantity: 100 Vien
Product quantity :  Add to Cart


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COMPOSITION:

  • Chlorpheniramine maleate .........................4 mg
  • Excipients q.s..........................................1 tablet

(Tapioca starch, lactose, gelatin, talc powder, magnesium stearate, aerosil, quinoline yellow).

DOSAGE FORM: Tablets.

ACTIONS: Chlorpheniramine is an anti-histamine H1 which antagonizes competitively and reversibly tohistamine H1-receptors.

Chlorpheniramine maleate is well absorbed by oral administration and occurs for 30 to 60 minutes in the plasma, peak plasma concentrations occurring about 2.5 to 6 hours. About 70% of Chlorpheniramine in the circulation is bound to plasma proteins. Unchanged drug and active metabolites are excreted primarily in the urine; excretion is dependent o­n urinary pH and flow-rate. The half-life is about 12 to 15 hours.

INDICATIONS: Allergic rhinitis, rhinorrhea, nasal stuffiness, coryza.

Other allergic symptoms such as urticaria, contact dermatitis, pruritus, food allergy, insect bites, allergic conjunctivitis, Quincke's oedema.

CONTRAINDICATIONS:

  • Hypersensitivity to chlorpheniramine and any components of the drug.
  • Pregnant women, nursing mothers, children < 6 months of age.
  • Patients with closed-angle glaucoma, prostatauxe, urinary retention.
  • Patients suffering from acute asthma.

PRECAUTIONS: Use with caution in patients with asthma, chronic pulmonary obstruction, hyperthyroidism and in the elderly.

The drug causes drowsiness, so drivers and machine operators are warned.

INTERACTIONS: Chlorpheniramine inhibits phenytoin metabolism. This can lead to phenytoin poisoning.

Narcotic tranquillizers, alcoholic drinks may increase the inhibitory effect of central nervous system of chlorpheniramine.

No combination with MAOIs.

ADVERSE EFFECTS: Drowsiness, anxiety, dryness of mouth, nausea, dizziness, headache, tenseness.

Inform your physician about any adverse effects occur during the treatment.

OVERDOSAGE: Symptoms of overdosage include sedation, psychosis, epilepsy, apnoea, convulsion, antiacetylcholine action …

Treatment: Gastric lavage or conduction of vomiting with Ipecacuanha syrup; then, using activated carbon or cathartic to limit absorption. Full supportive measures should also be instituted in case of hypotension and arrhythmia. Convulsions may be treated by intravenous injection of Diazepam or phenytoin.

DOSAGE & ADMINISTRATION:

Adults and children aged > 12 years: oral dose of 1 tablet, every 4 - 6 hrs. Do not exceed 6 tablets a day.

Or as directed by the physician.

Read the directions carefully before use.

Consult the physician for more information.

Shelf-life: 24 months from the manufacturing date.

Storage conditions: Store in cool, dry places; protect from light.

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